BLASTX 7.6.2
Query= RU22704 /QuerySize=1038
(1037 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54N38|UCHL5_DICDI Ubiquitin carboxyl-terminal hydrolase isoz... 290 2e-077
sp|Q9Y5K5|UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isoz... 289 4e-077
sp|Q9WUP7|UCHL5_MOUSE Ubiquitin carboxyl-terminal hydrolase isoz... 288 6e-077
sp|Q06AT3|UCHL5_PIG Ubiquitin carboxyl-terminal hydrolase isozym... 287 8e-077
sp|Q9XSJ0|UCHL5_BOVIN Ubiquitin carboxyl-terminal hydrolase isoz... 259 3e-068
sp|Q9UUB6|UBLH2_SCHPO Ubiquitin carboxyl-terminal hydrolase 2 OS... 237 9e-062
sp|Q09444|UBH4_CAEEL Probable ubiquitin carboxyl-terminal hydrol... 215 4e-055
sp|Q99PU7|BAP1_MOUSE Ubiquitin carboxyl-terminal hydrolase BAP1 ... 202 3e-051
sp|Q92560|BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 ... 201 6e-051
>sp|Q54N38|UCHL5_DICDI Ubiquitin carboxyl-terminal hydrolase isozyme L5
OS=Dictyostelium discoideum GN=uchl5 PE=3 SV=1
Length = 343
Score = 290 bits (740), Expect = 2e-077
Identities = 154/317 (48%), Positives = 207/317 (65%), Gaps = 18/317 (5%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDRL 769
WCTI+SDPGVFTELI ++ VK +QVEELY+LD + L+PV GLIFLFKW EK++
Sbjct: 7 WCTIESDPGVFTELITKIGVKDIQVEELYTLDSSEYDRLKPVLGLIFLFKW---EKEEEN 63
Query: 768 VIKDPNPNLFFASQVINNACATQAILSILLNCPDVDIGPELSKLKEFTKNFPPELKGLAI 589
N N+FFA+QVI NACATQAILS+LLN +++G ELS K F +FPP +KG AI
Sbjct: 64 RTISDNENIFFANQVIQNACATQAILSVLLNSEGIELGEELSNFKSFVGDFPPMMKGEAI 123
Query: 588 NNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPISLG 409
NSE I+ HNSF +PF+ ++K K D +HFIS++P G +YELDGLK+GP LG
Sbjct: 124 GNSELIKETHNSFTVQDPFIFSKKKNR-KPSDAFHFISFIPFQGKVYELDGLKKGPYCLG 182
Query: 408 QCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKKRER 229
C WL++ P IQ+R+E+YS+ EIRFNL+A +IKNR+ ++ L+KK+
Sbjct: 183 DCTPD----NWLEIATPFIQKRMEKYSQGEIRFNLMA-VIKNRQTTLQEKILTLEKKKND 237
Query: 228 ISQQLSILQSERPDDGSK---------FQALNKALSEVNAGIEGATEKILVEEEKFKKWR 76
+ +LS L S D + + LN ++ VN IE A +IL+E+EKF+ W+
Sbjct: 238 LEIKLSELNSGSGGDNKEESGGATPTTKEDLNFMINVVNNDIEEANNEILMEQEKFRNWK 297
Query: 75 TENIRRKHNYIPFFVQL 25
ENIRRKHN+ P + L
Sbjct: 298 DENIRRKHNFTPLILNL 314
>sp|Q9Y5K5|UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo
sapiens GN=UCHL5 PE=1 SV=3
Length = 329
Score = 289 bits (737), Expect = 4e-077
Identities = 151/313 (48%), Positives = 217/313 (69%), Gaps = 26/313 (8%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDRL 769
WC ++SDPGVFTELI+ +G QVEE++SL+ ++ L+PV+GLIFLFKW+PGE+
Sbjct: 8 WCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGS 67
Query: 768 VIKDPN-PNLFFASQVINNACATQAILSILLNC--PDVDIGPELSKLKEFTKNFPPELKG 598
V++D +FFA QVINNACATQAI+S+LLNC DV +G LS+ KEF+++F +KG
Sbjct: 68 VVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKG 127
Query: 597 LAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPI 418
LA++NS+ IR HNSFAR + F + K + K++D +HF+SY+PV+G LYELDGL+EGPI
Sbjct: 128 LALSNSDVIRQVHNSFARQQMF-EFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPI 186
Query: 417 SLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKK 238
LG C +W+ V+PVI++RI++YS+ EIRFNL+A I+ +RK +Y ++ ELQ++
Sbjct: 187 DLGAC----NQDDWISAVRPVIEKRIQKYSEGEIRFNLMA-IVSDRKMIYEQKIAELQRQ 241
Query: 237 RERISQQLSILQSERPDDGSKFQALNKALSEVNAGIEGATEKILVEEE--KFKKWRTENI 64
L E P D + ++ A+ E A ++L+EEE K K+++ ENI
Sbjct: 242 ----------LAEEEPMDTDQGNSMLSAIQS-----EVAKNQMLIEEEVQKLKRYKIENI 286
Query: 63 RRKHNYIPFFVQL 25
RRKHNY+PF ++L
Sbjct: 287 RRKHNYLPFIMEL 299
>sp|Q9WUP7|UCHL5_MOUSE Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Mus
musculus GN=Uchl5 PE=2 SV=2
Length = 329
Score = 288 bits (735), Expect = 6e-077
Identities = 152/313 (48%), Positives = 215/313 (68%), Gaps = 26/313 (8%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDRL 769
WC ++SDPGVFTELI+ +G QVEE++SL+ +S L+PV+GLIFLFKW+PGE+
Sbjct: 8 WCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGS 67
Query: 768 VIKDPN-PNLFFASQVINNACATQAILSILLNC--PDVDIGPELSKLKEFTKNFPPELKG 598
V++D +FFA QVINNACATQAI+S+LLNC DV +G LS+ KEF+++F +KG
Sbjct: 68 VVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKG 127
Query: 597 LAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPI 418
LA++NS+ IR HNSFAR + F + K K++D +HF+SY+PV+G LYELDGL+EGPI
Sbjct: 128 LALSNSDVIRQVHNSFARQQMF-EFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPI 186
Query: 417 SLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKK 238
LG C +W+ V+PVI++RI++YS+ EIRFNL+A I+ +RK +Y ++ ELQ++
Sbjct: 187 DLGAC----NQDDWITAVRPVIEKRIQKYSEGEIRFNLMA-IVSDRKMIYEQKIAELQRQ 241
Query: 237 RERISQQLSILQSERPDDGSKFQALNKALSEVNAGIEGATEKILVEEE--KFKKWRTENI 64
L E P D + + A+ E A ++L+EEE K K+++ ENI
Sbjct: 242 ----------LAEEEPMDTDQGSTVLSAIQS-----EVARNQMLIEEEVQKLKRYKIENI 286
Query: 63 RRKHNYIPFFVQL 25
RRKHNY+PF ++L
Sbjct: 287 RRKHNYLPFIMEL 299
>sp|Q06AT3|UCHL5_PIG Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Sus
scrofa GN=UCHL5 PE=2 SV=1
Length = 329
Score = 287 bits (734), Expect = 8e-077
Identities = 151/313 (48%), Positives = 216/313 (69%), Gaps = 26/313 (8%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDRL 769
WC ++SDPGVFTELI+ +G QVEE++SL+ ++ L+PV+GLIFLFKW+PGE+
Sbjct: 8 WCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGS 67
Query: 768 VIKDPN-PNLFFASQVINNACATQAILSILLNC--PDVDIGPELSKLKEFTKNFPPELKG 598
V++D +FFA QVINNACATQAI+S+LLNC DV +G LS+ KEF+++F +KG
Sbjct: 68 VVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKG 127
Query: 597 LAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPI 418
LA++NS+ IR HNSFAR + F + K + K++D +HF+SY+PV+G LYELDGL+EGPI
Sbjct: 128 LALSNSDVIRQVHNSFARQQMF-EFDAKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPI 186
Query: 417 SLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKK 238
LG C +W+ V+PVI++RI++YS+ EIRFNL+A I+ +RK +Y ++ ELQ++
Sbjct: 187 DLGAC----NQDDWISAVRPVIEKRIQKYSEGEIRFNLMA-IVSDRKMIYEQKIAELQRQ 241
Query: 237 RERISQQLSILQSERPDDGSKFQALNKALSEVNAGIEGATEKILVEEE--KFKKWRTENI 64
L E P D + + A+ E A ++L+EEE K K+++ ENI
Sbjct: 242 ----------LAEEEPMDTDQGSNMLSAIQS-----EVAKNQMLIEEEVQKLKRYKIENI 286
Query: 63 RRKHNYIPFFVQL 25
RRKHNY+PF ++L
Sbjct: 287 RRKHNYLPFIMEL 299
>sp|Q9XSJ0|UCHL5_BOVIN Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos
taurus GN=UCHL5 PE=2 SV=1
Length = 328
Score = 259 bits (660), Expect = 3e-068
Identities = 133/261 (50%), Positives = 188/261 (72%), Gaps = 16/261 (6%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDRL 769
WC ++SDPGVFTELI+ +G QVEE++SL+ ++ L+PV+GLIFLFKW+PGE+
Sbjct: 8 WCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGS 67
Query: 768 VIKDPN-PNLFFASQVINNACATQAILSILLNC--PDVDIGPELSKLKEFTKNFPPELKG 598
V++D +FFA QVINNACATQAI+S+LLNC DV +G LS+ KEF+++F +KG
Sbjct: 68 VVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKG 127
Query: 597 LAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPI 418
LA++NS+ IR HNSFAR + F + K A K++D +HF+SY+PV+G LYELDGL+EGPI
Sbjct: 128 LALSNSDVIRQVHNSFARQQMF-EFDAKTAAKEEDAFHFVSYVPVNGRLYELDGLREGPI 186
Query: 417 SLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKK 238
LG C +W+ V+PVI++RI++YS+ EIRFNL+A I+ +RK +Y ++ ELQ++
Sbjct: 187 DLGAC----NQDDWISAVRPVIEKRIQKYSEGEIRFNLMA-IVSDRKMIYEQKIAELQRQ 241
Query: 237 -------RERISQQLSILQSE 196
++ S LS +QSE
Sbjct: 242 LAEEPMDTDQGSNMLSAIQSE 262
>sp|Q9UUB6|UBLH2_SCHPO Ubiquitin carboxyl-terminal hydrolase 2
OS=Schizosaccharomyces pombe GN=uch2 PE=1 SV=1
Length = 300
Score = 237 bits (604), Expect = 9e-062
Identities = 123/234 (52%), Positives = 159/234 (67%), Gaps = 6/234 (2%)
Frame = -3
Query: 954 MSWCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPG-EKD 778
MSW TI+SD GVFT+LI+ + VK V+V+ELYSLD+DSL +YG+IFLFKW +K
Sbjct: 1 MSWTTIESDAGVFTDLIENLGVKDVEVDELYSLDVDSLRQFPDIYGIIFLFKWNSKVDKP 60
Query: 777 DRLVIKDPNPNLFFASQVINNACATQAILSILLNCPD-VDIGPELSKLKEFTKNFPPELK 601
D + D N+FFA QVINNACATQA+LS+LLN D +D+G LS+ K+F+K PPELK
Sbjct: 61 DGTMDYDSMDNIFFAKQVINNACATQALLSVLLNHSDEIDLGTTLSEFKDFSKTLPPELK 120
Query: 600 GLAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGP 421
G A+ NSE IR HNSFAR +PF+ EE +AA +D+VYHFI+Y ++ V YELDGL+ P
Sbjct: 121 GEALGNSEHIRCCHNSFARSDPFISEEVRAATDEDEVYHFIAYTNINNVFYELDGLQAAP 180
Query: 420 ISLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVE 259
I+ G C E+ + VIQ RI Y +EIRFNL+ I + + T E
Sbjct: 181 INHGSCT----KEEFAEKAVSVIQARIANYDPAEIRFNLMVICKDKKASLLTRE 230
>sp|Q09444|UBH4_CAEEL Probable ubiquitin carboxyl-terminal hydrolase ubh-4
OS=Caenorhabditis elegans GN=ubh-4 PE=1 SV=2
Length = 321
Score = 215 bits (547), Expect = 4e-055
Identities = 115/269 (42%), Positives = 171/269 (63%), Gaps = 13/269 (4%)
Frame = -3
Query: 951 SWCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEKDDR 772
SWC I+SDPGVFTE+++ V G+QVEELYSLD D + RP YGLIFLFKWR G D+
Sbjct: 6 SWCLIESDPGVFTEMLRGFGVDGLQVEELYSLDDDKAMT-RPTYGLIFLFKWRQG--DET 62
Query: 771 LVIKDPNPNLFFASQVINNACATQAILSILLNCPDVDI--GPELSKLKEFTKNFPPELKG 598
I N+FFA Q I NACATQA++++L+N D D+ G L++ KEF + P +G
Sbjct: 63 TGIPSDKQNIFFAHQTIQNACATQALINLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRG 122
Query: 597 LAINNSEAIRAAHNSFARPEPFVPEEQKAAGKDDDVYHFISYLPVDGVLYELDGLKEGPI 418
++NSE IR HNSF+R F E G+ +D YHF++Y+P+ +YELDGL+E P+
Sbjct: 123 HCLSNSEEIRTVHNSFSRQTLF--ELDIKGGESEDNYHFVTYVPIGNKVYELDGLRELPL 180
Query: 417 SLGQCPGGQGDMEWLQMVQPVIQERIERYSKSEIRFNLLAIIIKNRKEMYTVELKELQKK 238
+ + Q + +W++ ++PVIQ+R+++YS+ EI FNL+A ++ NRK+ ++ L +
Sbjct: 181 EVAEF---QKEQDWIEAIKPVIQQRMQKYSEGEITFNLMA-LVPNRKQKLQEMMENLIQA 236
Query: 237 RE--RISQQLSILQSERPDDGSKFQALNK 157
E + +Q++ L D+ K + K
Sbjct: 237 NENNELEEQIADLNKAIADEDYKMEMYRK 265
>sp|Q99PU7|BAP1_MOUSE Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Mus musculus
GN=Bap1 PE=1 SV=1
Length = 728
Score = 202 bits (513), Expect = 3e-051
Identities = 126/309 (40%), Positives = 176/309 (56%), Gaps = 33/309 (10%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEK---- 781
W ++SDPG+FT L++ VKGVQVEE+Y L PVYG IFLFKW +
Sbjct: 5 WLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQG---PVYGFIFLFKWIEERRSRRK 61
Query: 780 -----DDRLVIKDP-NPNLFFASQVINNACATQAILSILLNCPDVDIGPELSKLKEFTKN 619
DD VI D N+FFA Q+I N+CAT A+LS+LLNC +VD+GP LS++K+FTK
Sbjct: 62 VSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKG 121
Query: 618 FPPELKGLAINNSEAIRAAHNSFARPEP-FVPEEQK--AAGKDDDVYHFISYLPVDGVLY 448
F PE KG AI N+ + AHNS ARPEP +PE+Q +A + + +HF+SY+P+ G L+
Sbjct: 122 FSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF 181
Query: 447 ELDGLKEGPISLGQCPGGQGDMEWLQMVQPVIQERIERYSKSE----IRFNLLAIIIKNR 280
ELDGLK PI G P G+ D EW + VI ERI + E IRFNL+A ++ +R
Sbjct: 182 ELDGLKVYPIDHG--PWGE-DEEWTDKARRVIMERIGLATAGEPYHDIRFNLMA-VVPDR 237
Query: 279 KEMYTVELKELQKKRERISQQL---------SILQSERPDDGSKFQALNKALSEVNAGIE 127
+ Y L L+ R+ + + L ++Q+ + + + A S+ G+E
Sbjct: 238 RIKYETRLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLGLE 297
Query: 126 GATEKILVE 100
+ E
Sbjct: 298 AGRTPVASE 306
>sp|Q92560|BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens
GN=BAP1 PE=1 SV=2
Length = 729
Score = 201 bits (511), Expect = 6e-051
Identities = 121/265 (45%), Positives = 161/265 (60%), Gaps = 24/265 (9%)
Frame = -3
Query: 948 WCTIDSDPGVFTELIQQMQVKGVQVEELYSLDIDSLNSLRPVYGLIFLFKWRPGEK---- 781
W ++SDPG+FT L++ VKGVQVEE+Y L PVYG IFLFKW +
Sbjct: 5 WLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQG---PVYGFIFLFKWIEERRSRRK 61
Query: 780 -----DDRLVIKDP-NPNLFFASQVINNACATQAILSILLNCPDVDIGPELSKLKEFTKN 619
DD VI D N+FFA Q+I N+CAT A+LS+LLNC VD+GP LS++K+FTK
Sbjct: 62 VSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKG 121
Query: 618 FPPELKGLAINNSEAIRAAHNSFARPEP-FVPEEQK--AAGKDDDVYHFISYLPVDGVLY 448
F PE KG AI N+ + AHNS ARPEP +PE+Q +A + + +HF+SY+P+ G L+
Sbjct: 122 FSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF 181
Query: 447 ELDGLKEGPISLGQCPGGQGDMEWLQMVQPVIQERIERYSKSE----IRFNLLAIIIKNR 280
ELDGLK PI G P G+ D EW + VI ERI + E IRFNL+A ++ +R
Sbjct: 182 ELDGLKVYPIDHG--PWGE-DEEWTDKARRVIMERIGLATAGEPYHDIRFNLMA-VVPDR 237
Query: 279 KEMYTVELKELQKKRERISQQLSIL 205
+ Y L L+ R+ + + L L
Sbjct: 238 RIKYEARLHVLKVNRQTVLEALQQL 262
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,872,341,632
Number of Sequences: 462764
Number of Extensions: 23872341632
Number of Successful Extensions: 226348076
Number of sequences better than 0.0: 0
|