BLASTX 7.6.2
Query= RU24285 /QuerySize=1039
(1038 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9W725|UCP2_CYPCA Mitochondrial uncoupling protein 2 OS=Cypri... 198 5e-050
sp|O77792|UCP3_BOVIN Mitochondrial uncoupling protein 3 OS=Bos t... 196 2e-049
sp|O97649|UCP3_PIG Mitochondrial uncoupling protein 3 OS=Sus scr... 196 2e-049
sp|Q9W720|UCP2_DANRE Mitochondrial uncoupling protein 2 OS=Danio... 196 3e-049
sp|P56500|UCP2_RAT Mitochondrial uncoupling protein 2 OS=Rattus ... 196 3e-049
sp|P70406|UCP2_MOUSE Mitochondrial uncoupling protein 2 OS=Mus m... 195 4e-049
sp|P56501|UCP3_MOUSE Mitochondrial uncoupling protein 3 OS=Mus m... 195 4e-049
sp|Q9N2I9|UCP3_CANFA Mitochondrial uncoupling protein 3 OS=Canis... 195 5e-049
sp|Q3SZI5|UCP2_BOVIN Mitochondrial uncoupling protein 2 OS=Bos t... 195 7e-049
sp|P56499|UCP3_RAT Mitochondrial uncoupling protein 3 OS=Rattus ... 195 7e-049
sp|O97562|UCP2_PIG Mitochondrial uncoupling protein 2 OS=Sus scr... 193 2e-048
sp|P55851|UCP2_HUMAN Mitochondrial uncoupling protein 2 OS=Homo ... 191 8e-048
sp|Q5R5A8|UCP2_PONAB Mitochondrial uncoupling protein 2 OS=Pongo... 191 8e-048
sp|P55916|UCP3_HUMAN Mitochondrial uncoupling protein 3 OS=Homo ... 191 8e-048
sp|Q9N2J1|UCP2_CANFA Mitochondrial uncoupling protein 2 OS=Canis... 188 5e-047
sp|Q9GMZ1|UCP1_CANFA Mitochondrial brown fat uncoupling protein ... 178 9e-044
sp|P25874|UCP1_HUMAN Mitochondrial brown fat uncoupling protein ... 169 3e-041
sp|A0PC02|UCP1_OCHDA Mitochondrial brown fat uncoupling protein ... 166 3e-040
sp|P04633|UCP1_RAT Mitochondrial brown fat uncoupling protein 1 ... 165 5e-040
sp|P12242|UCP1_MOUSE Mitochondrial brown fat uncoupling protein ... 164 1e-039
sp|Q9ER18|UCP1_PHOSU Mitochondrial brown fat uncoupling protein ... 163 3e-039
sp|P14271|UCP1_RABIT Mitochondrial brown fat uncoupling protein ... 162 4e-039
sp|Q8K404|UCP1_DICGR Mitochondrial brown fat uncoupling protein ... 161 7e-039
sp|P10861|UCP1_BOVIN Mitochondrial brown fat uncoupling protein ... 153 3e-036
sp|Q54PY7|M2OM_DICDI Probable mitochondrial 2-oxoglutarate/malat... 140 2e-032
sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate carrier... 122 3e-027
sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier... 122 4e-027
sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier OS=Mus m... 119 3e-026
sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier... 119 5e-026
sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carrier p... 118 6e-026
>sp|Q9W725|UCP2_CYPCA Mitochondrial uncoupling protein 2 OS=Cyprinus carpio
GN=ucp2 PE=2 SV=1
Length = 310
Score = 198 bits (503), Expect = 5e-050
Identities = 110/262 (41%), Positives = 146/262 (55%), Gaps = 7/262 (2%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + KYRG+ GT++T+ R EG +L+ G+V GL
Sbjct: 28 DLFTFPLDTAKVRLQIQGESKIPVNTGHGPVKYRGVFGTISTMVRVEGPRSLYSGLVAGL 87
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ VG +A PTD+VKVR
Sbjct: 88 QRQMSFASVRIGLYDSVKQFYTKGSEHVG---IGSRLMAGCTTGAMAVALAQPTDVVKVR 144
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ GA +RY G ++AY TI ++EG LW G GP EL +YD +K
Sbjct: 145 FQAQNS--AGANKRYHGTMDAYRTIAKEEGFRGLWKGTGPNITRNAIVNCTELVTYDLIK 202
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
LLK D++ H + GAGF I SPVDVVK+R M + Y S ++C V L
Sbjct: 203 DALLKSSLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAPGQYCSALNCAVAML 262
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+GP AFYKGF+P+F RLGSW
Sbjct: 263 TKEGPKAFYKGFMPSFLRLGSW 284
>sp|O77792|UCP3_BOVIN Mitochondrial uncoupling protein 3 OS=Bos taurus GN=UCP3
PE=2 SV=1
Length = 311
Score = 196 bits (498), Expect = 2e-049
Identities = 109/263 (41%), Positives = 142/263 (53%), Gaps = 8/263 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLLTFPLDTAKVRLQIQGENQAALAARSA--QYRGVLGTILTMVRTEGPRSLYSGLVAGL 85
Query: 601 HRQCLYGGLRIGLYDPIKTLYV--GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKV 428
RQ + +RIGLYD +K Y G+D + A PTD+VK+
Sbjct: 86 QRQMSFASIRIGLYDSVKQFYTPKGSDHSSII---TRILAGCTTGAMAVTCAQPTDVVKI 142
Query: 427 RLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQV 248
R QA G R+YSG ++AY TI R+EGV LW GI P E+ +YD +
Sbjct: 143 RFQASMHTGLGGNRKYSGTMDAYRTIAREEGVRGLWKGILPNITRNAIVNCGEMVTYDII 202
Query: 247 KQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKT 71
K+ LL DN H + GAGF A + SPVDVVK+R M Y S DC +K
Sbjct: 203 KEKLLDYHLLTDNFPCHFVSAFGAGFCATLVASPVDVVKTRYMNSPPGQYHSPFDCMLKM 262
Query: 70 LKNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF P+F RLGSW
Sbjct: 263 VTQEGPTAFYKGFTPSFLRLGSW 285
>sp|O97649|UCP3_PIG Mitochondrial uncoupling protein 3 OS=Sus scrofa GN=UCP3
PE=2 SV=1
Length = 308
Score = 196 bits (498), Expect = 2e-049
Identities = 108/263 (41%), Positives = 145/263 (55%), Gaps = 11/263 (4%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG + + G+V GL
Sbjct: 28 DLLTFPLDTAKVRLQIQGENQAARSA-----QYRGVLGTILTMVRNEGPRSPYNGLVAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYV--GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKV 428
RQ + +RIGLYD +K LY G+D A PTD+VKV
Sbjct: 83 QRQMSFASIRIGLYDSVKQLYTPKGSDHSS---ITTRILAGCTTGAMAVTCAQPTDVVKV 139
Query: 427 RLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQV 248
R QA P + R+YSG ++AY TI R+EGV LW GI P E+ +YD +
Sbjct: 140 RFQASIHAGPRSNRKYSGTMDAYRTIAREEGVRGLWKGILPNITRNAIVNCAEMVTYDVI 199
Query: 247 KQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKT 71
K+ +L DN+ H + GAGF A + SPVDVVK+R M Y++ +DC +K
Sbjct: 200 KEKVLDYHLLTDNLPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYQNPLDCMLKM 259
Query: 70 LKNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF P+F RLGSW
Sbjct: 260 VTQEGPTAFYKGFTPSFLRLGSW 282
>sp|Q9W720|UCP2_DANRE Mitochondrial uncoupling protein 2 OS=Danio rerio GN=ucp2
PE=2 SV=1
Length = 310
Score = 196 bits (496), Expect = 3e-049
Identities = 108/262 (41%), Positives = 144/262 (54%), Gaps = 7/262 (2%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + KYRG+ GT++T+ R EG +L+ G+V GL
Sbjct: 28 DLFTFPLDTAKVRLQIQGENKASTNMGRGPVKYRGVFGTISTMVRVEGPRSLYSGLVAGL 87
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G+D G VA PTD++KVR
Sbjct: 88 QRQMSFASVRIGLYDSVKQFYTKGSDHAG---IGSRLMAGCTTGAMAVAVAQPTDVLKVR 144
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + GA +RY ++AY TI ++EG LW G GP EL +YD +K
Sbjct: 145 FQAQ--VSAGASKRYHSTMDAYRTIAKEEGFRGLWKGTGPNITRNAIVNCTELVTYDLIK 202
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
LLK D++ H + GAGF I SPVDVVK+R M + Y S ++C V L
Sbjct: 203 DALLKSSLMTDDLPCHFTSAFGAGFCTTIIASPVDVVKTRYMNSAQGQYSSALNCAVAML 262
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
GP AF+KGF+P+F RLGSW
Sbjct: 263 TKKGPKAFFKGFMPSFLRLGSW 284
>sp|P56500|UCP2_RAT Mitochondrial uncoupling protein 2 OS=Rattus norvegicus
GN=Ucp2 PE=2 SV=1
Length = 309
Score = 196 bits (496), Expect = 3e-049
Identities = 109/262 (41%), Positives = 143/262 (54%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGESQGLARTAAS-AQYRGVLGTILTMVRTEGPRSLYNGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ G VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHAG---IGSRLLAGSTTGALAVAVAQPTDVVKVR 143
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + G RRY + AY TI R+EG+ LW G P EL +YD +K
Sbjct: 144 FQAQAR--AGGGRRYQSTVEAYKTIAREEGIRGLWKGTSPNVARNAIVNCTELVTYDLIK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
TLLK D++ H + GAGF I SPVDVVK+R M + Y S C + L
Sbjct: 202 DTLLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF+P+F RLGSW
Sbjct: 262 RKEGPRAFYKGFMPSFLRLGSW 283
>sp|P70406|UCP2_MOUSE Mitochondrial uncoupling protein 2 OS=Mus musculus GN=Ucp2
PE=2 SV=1
Length = 309
Score = 195 bits (495), Expect = 4e-049
Identities = 109/262 (41%), Positives = 143/262 (54%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGESQGLVRTAAS-AQYRGVLGTILTMVRTEGPRSLYNGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ G VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHAG---IGSRLLAGSTTGALAVAVAQPTDVVKVR 143
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + G RRY + AY TI R+EG+ LW G P EL +YD +K
Sbjct: 144 FQAQAR--AGGGRRYQSTVEAYKTIAREEGIRGLWKGTSPNVARNAIVNCAELVTYDLIK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
TLLK D++ H + GAGF I SPVDVVK+R M + Y S C + L
Sbjct: 202 DTLLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF+P+F RLGSW
Sbjct: 262 RKEGPRAFYKGFMPSFLRLGSW 283
>sp|P56501|UCP3_MOUSE Mitochondrial uncoupling protein 3 OS=Mus musculus GN=Ucp3
PE=2 SV=1
Length = 308
Score = 195 bits (495), Expect = 4e-049
Identities = 106/261 (40%), Positives = 142/261 (54%), Gaps = 7/261 (2%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG + + G+V GL
Sbjct: 28 DLLTFPLDTAKVRLQIQGENPGAQSV-----QYRGVLGTILTMVRTEGPRSPYSGLVAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
HRQ + +RIGLYD +K Y A PTD+VKVR
Sbjct: 83 HRQMSFASIRIGLYDSVKQFYTPKG-ADHSSVAIRILAGCTTGAMAVTCAQPTDVVKVRF 141
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA +L G R+Y G ++AY TI R+EGV LW G P E+ +YD +K+
Sbjct: 142 QAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDIIKE 201
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMM-GDSAAYKSTIDCFVKTLK 65
LL+ F DN H + GAGF A + SPVDVVK+R M Y+S + C +K +
Sbjct: 202 KLLESHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPLGRYRSPLHCMLKMVA 261
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AFYKGF+P+F RLG+W
Sbjct: 262 QEGPTAFYKGFVPSFLRLGAW 282
>sp|Q9N2I9|UCP3_CANFA Mitochondrial uncoupling protein 3 OS=Canis familiaris
GN=UCP3 PE=2 SV=1
Length = 311
Score = 195 bits (494), Expect = 5e-049
Identities = 109/263 (41%), Positives = 143/263 (54%), Gaps = 8/263 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG + + G+V GL
Sbjct: 28 DLLTFPLDTAKVRLQIQGENQATQAARRI--QYRGVLGTILTMVRTEGPRSPYNGLVAGL 85
Query: 601 HRQCLYGGLRIGLYDPIKTLYV--GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKV 428
RQ + +RIGLYD +K Y G+D A PTD+VKV
Sbjct: 86 QRQMSFASIRIGLYDSVKQFYTPKGSDHSS---ITTRILAGCTTGAMAVSCAQPTDVVKV 142
Query: 427 RLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQV 248
R QA L G+ R+YSG ++AY TI R+EGV LW G P E+ +YD +
Sbjct: 143 RFQASIHLGAGSNRKYSGTMDAYRTIAREEGVRGLWKGTLPNITRNAIVNCAEMVTYDII 202
Query: 247 KQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKT 71
K+ LL DN HL + GAGF A + SPVDVVK+R M Y S +DC +K
Sbjct: 203 KEKLLDYHLLTDNFPCHLISAFGAGFCATVVASPVDVVKTRYMNSPPGQYCSPLDCMLKM 262
Query: 70 LKNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF P+F RLG+W
Sbjct: 263 VTQEGPTAFYKGFTPSFLRLGTW 285
>sp|Q3SZI5|UCP2_BOVIN Mitochondrial uncoupling protein 2 OS=Bos taurus GN=UCP2
PE=2 SV=1
Length = 309
Score = 195 bits (493), Expect = 7e-049
Identities = 110/262 (41%), Positives = 143/262 (54%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGERQGPMQAAAS-AQYRGVLGTILTMVRTEGPRSLYSGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ G VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHAG---IGSRLLAGSTTGALAVAVAQPTDVVKVR 143
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + GA RRY + AY TI R+EG LW G P EL +YD +K
Sbjct: 144 FQAQAR--AGAGRRYQSTVEAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
TLLK D++ H + GAGF I SPVDVVK+R M + Y S C + L
Sbjct: 202 DTLLKAHLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF+P+F RLGSW
Sbjct: 262 QKEGPQAFYKGFMPSFLRLGSW 283
>sp|P56499|UCP3_RAT Mitochondrial uncoupling protein 3 OS=Rattus norvegicus
GN=Ucp3 PE=2 SV=1
Length = 308
Score = 195 bits (493), Expect = 7e-049
Identities = 108/263 (41%), Positives = 143/263 (54%), Gaps = 11/263 (4%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG + + G+V GL
Sbjct: 28 DLLTFPLDTAKVRLQIQGENPGVQSV-----QYRGVLGTILTMVRTEGPRSPYSGLVAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYV--GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKV 428
HRQ + +RIGLYD +K Y G D A PTD+VKV
Sbjct: 83 HRQMSFASIRIGLYDSVKQFYTPKGTDHSS---VAIRILAGCTTGAMAVTCAQPTDVVKV 139
Query: 427 RLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQV 248
R QA +L G R+Y G ++AY TI R+EGV LW G P E+ +YD +
Sbjct: 140 RFQAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDII 199
Query: 247 KQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMM-GDSAAYKSTIDCFVKT 71
K+ LL F DN H + GAGF A + SPVDVVK+R M Y+S + C ++
Sbjct: 200 KEKLLDSHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPPGRYRSPLHCMLRM 259
Query: 70 LKNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF+P+F RLGSW
Sbjct: 260 VAQEGPTAFYKGFMPSFLRLGSW 282
>sp|O97562|UCP2_PIG Mitochondrial uncoupling protein 2 OS=Sus scrofa GN=UCP2
PE=2 SV=1
Length = 309
Score = 193 bits (490), Expect = 2e-048
Identities = 109/262 (41%), Positives = 143/262 (54%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+LGT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGERRGPVQAAAS-AQYRGVLGTILTMVRNEGPRSLYNGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ G VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKHFYTKGSEHAG---IGSRLLAGSTTGALAVAVAQPTDVVKVR 143
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + G RRY ++AY TI R+EG+ LW G P EL +YD +K
Sbjct: 144 FQAQAR--AGGGRRYRSTVDAYKTIAREEGLRGLWKGTSPNVARNAIVNCAELVTYDLIK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
TLLK D++ H + GAGF I SPVDVVK+R M + Y S C + L
Sbjct: 202 DTLLKADLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAPGQYSSAGHCALTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF P+F RLGSW
Sbjct: 262 QKEGPRAFYKGFTPSFLRLGSW 283
>sp|P55851|UCP2_HUMAN Mitochondrial uncoupling protein 2 OS=Homo sapiens GN=UCP2
PE=2 SV=1
Length = 309
Score = 191 bits (484), Expect = 8e-048
Identities = 106/261 (40%), Positives = 139/261 (53%), Gaps = 6/261 (2%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG++GT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGESQGPVRATAS-AQYRGVMGTILTMVRTEGPRSLYNGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + +RIGLYD +K Y + VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHASI--GSRLLAGSTTGALAVAVAQPTDVVKVRF 144
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ + G RRY +NAY TI R+EG LW G P EL +YD +K
Sbjct: 145 QAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTLK 65
LLK D++ H + GAGF I SPVDVVK+R M + Y S C + L+
Sbjct: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQ 262
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AFYKGF+P+F RLGSW
Sbjct: 263 KEGPRAFYKGFMPSFLRLGSW 283
>sp|Q5R5A8|UCP2_PONAB Mitochondrial uncoupling protein 2 OS=Pongo abelii GN=UCP2
PE=2 SV=1
Length = 309
Score = 191 bits (484), Expect = 8e-048
Identities = 106/261 (40%), Positives = 139/261 (53%), Gaps = 6/261 (2%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG++GT+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGESQGPVHATAS-AQYRGVMGTILTMVRTEGPRSLYNGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + +RIGLYD +K Y + VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHASI--GSRLLAGSTTGALAVAVAQPTDVVKVRF 144
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ + G RRY +NAY TI R+EG LW G P EL +YD +K
Sbjct: 145 QAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTLK 65
LLK D++ H + GAGF I SPVDVVK+R M + Y S C + L+
Sbjct: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQ 262
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AFYKGF+P+F RLGSW
Sbjct: 263 KEGPRAFYKGFMPSFLRLGSW 283
>sp|P55916|UCP3_HUMAN Mitochondrial uncoupling protein 3 OS=Homo sapiens GN=UCP3
PE=1 SV=1
Length = 312
Score = 191 bits (484), Expect = 8e-048
Identities = 108/262 (41%), Positives = 142/262 (54%), Gaps = 5/262 (1%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + L +YRG+LGT+ T+ R EG + + G+V GL
Sbjct: 28 DLVTFPLDTAKVRLQIQGE--NQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGL 85
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + +RIGLYD +K +Y + A PTD+VKVR
Sbjct: 86 QRQMSFASIRIGLYDSVKQVYTPKG-ADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRF 144
Query: 421 QAEGKLPPG-APRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA L P + R+YSG ++AY TI R+EGV LW G P E+ +YD +K
Sbjct: 145 QASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILK 204
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTL 68
+ LL DN H + GAGF A + SPVDVVK+R M Y S +DC +K +
Sbjct: 205 EKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMV 264
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+GP AFYKGF P+F RLGSW
Sbjct: 265 AQEGPTAFYKGFTPSFLRLGSW 286
>sp|Q9N2J1|UCP2_CANFA Mitochondrial uncoupling protein 2 OS=Canis familiaris
GN=UCP2 PE=2 SV=1
Length = 309
Score = 188 bits (477), Expect = 5e-047
Identities = 107/262 (40%), Positives = 142/262 (54%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +YRG+L T+ T+ R EG +L+ G+V GL
Sbjct: 28 DLITFPLDTAKVRLQIQGERQGPVRAAAS-AQYRGVLCTILTMVRTEGPRSLYSGLVAGL 86
Query: 601 HRQCLYGGLRIGLYDPIKTLYV-GNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + +RIGLYD +K Y G++ G VA PTD+VKVR
Sbjct: 87 QRQMSFASVRIGLYDSVKQFYTKGSEHAG---IGSRLLAGSTTGALAVAVAQPTDVVKVR 143
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
QA+ + G+ RRY ++AY TI R+EG LW G P EL +YD +K
Sbjct: 144 FQAQAR--AGSGRRYQSTVDAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGDS-AAYKSTIDCFVKTL 68
LLK D++ H + GAGF I SPVDVVK+R M + Y S C + L
Sbjct: 202 DALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+ +GP AFYKGF+P+F RLGSW
Sbjct: 262 QKEGPRAFYKGFMPSFLRLGSW 283
>sp|Q9GMZ1|UCP1_CANFA Mitochondrial brown fat uncoupling protein 1 OS=Canis
familiaris GN=UCP1 PE=2 SV=1
Length = 309
Score = 178 bits (449), Expect = 9e-044
Identities = 106/262 (40%), Positives = 141/262 (53%), Gaps = 8/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + P+YRG+LGTVAT+AR EGL L+ G+ GL
Sbjct: 28 DMITFPLDTAKVRLQIQGEGQGQPPRA---PRYRGVLGTVATLARTEGLQKLYSGLPAGL 84
Query: 601 HRQCLYGGLRIGLYDPIKT-LYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ + LRIGLYD ++ L G + + PT++VKVR
Sbjct: 85 QRQVGFASLRIGLYDSVREWLSPGQGAAASL--GSRISAGVMTGGAAVFIGQPTEVVKVR 142
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
LQA+ L G RY+G NAY I EG+ LW G P EL +YD +K
Sbjct: 143 LQAQSHL-HGRKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRNVIINCTELVTYDLMK 201
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTL 68
+ L+K D++ H + L AGF + SPVDVVK+R + Y S +C + L
Sbjct: 202 EALVKNHLLADDLPCHFLSALVAGFCTTVLSSPVDVVKTRFVNSVPEQYTSVPNCAMTML 261
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
+GPLAF+KGF+P+F RLGSW
Sbjct: 262 TKEGPLAFFKGFVPSFLRLGSW 283
>sp|P25874|UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 OS=Homo
sapiens GN=UCP1 PE=2 SV=3
Length = 307
Score = 169 bits (427), Expect = 3e-041
Identities = 100/262 (38%), Positives = 138/262 (52%), Gaps = 10/262 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + + +Y+G+LGT+ V + EG L+ G+ GL
Sbjct: 28 DVITFPLDTAKVRLQVQGE-----CPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKT-LYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVR 425
RQ LRIGLYD ++ L G + + + PT++VKVR
Sbjct: 83 QRQISSASLRIGLYDTVQEFLTAGKETAPSL--GSKILAGLTTGGVAVFIGQPTEVVKVR 140
Query: 424 LQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVK 245
LQA+ L G RY+G NAY I EG+ LW G P EL +YD +K
Sbjct: 141 LQAQSHL-HGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMK 199
Query: 244 QTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTL 68
+ +K D++ HL + L AGF A + SPVDVVK+R + YKS +C +K
Sbjct: 200 EAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVF 259
Query: 67 KNDGPLAFYKGFIPNFGRLGSW 2
N+GP AF+KG +P+F RLGSW
Sbjct: 260 TNEGPTAFFKGLVPSFLRLGSW 281
>sp|A0PC02|UCP1_OCHDA Mitochondrial brown fat uncoupling protein 1 OS=Ochotona
daurica GN=UCP1 PE=2 SV=1
Length = 306
Score = 166 bits (418), Expect = 3e-040
Identities = 96/261 (36%), Positives = 134/261 (51%), Gaps = 9/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVRLQ+Q + +Y+G+LGT+ T+A+ EG L+ G+ GL
Sbjct: 28 DVITFPLDTAKVRLQIQGECQTTSGI-----RYKGVLGTITTLAKTEGPLKLYSGLPAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ + G + + + PT++VKVRL
Sbjct: 83 QRQISFASLRIGLYDTVQEFWGGEEATPSL--RSKICAGLTTGGVAVFIGQPTEVVKVRL 140
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E + LW G P EL +YD +K
Sbjct: 141 QAQSHL-HGLKPRYTGTYNAYRIIATTESLSTLWKGTTPNLLRNIIINCTELVTYDLMKG 199
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L++ D++ HL + L AGF + SPVDVVK+R + Y S C + L
Sbjct: 200 ALVRNDILADDVPCHLLSALIAGFCTTLLSSPVDVVKTRFINSPQGQYTSVPSCAMSMLT 259
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF P+F RL SW
Sbjct: 260 KEGPTAFFKGFAPSFLRLASW 280
>sp|P04633|UCP1_RAT Mitochondrial brown fat uncoupling protein 1 OS=Rattus
norvegicus GN=Ucp1 PE=1 SV=2
Length = 307
Score = 165 bits (417), Expect = 5e-040
Identities = 96/261 (36%), Positives = 132/261 (50%), Gaps = 8/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
+I T PLDTAKVRLQ+Q + +Y+G+LGT+ T+A+ EGL L+ G+ G+
Sbjct: 28 DIITFPLDTAKVRLQIQGEGQASSTI-----RYKGVLGTITTLAKTEGLPKLYSGLPAGI 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ Y + + PT++VKVR+
Sbjct: 83 QRQISFASLRIGLYDTVQE-YFSSGRETPASLGSKISAGLMTGGVAVFIGQPTEVVKVRM 141
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E + LW G P EL +YD +K
Sbjct: 142 QAQSHL-HGIKPRYTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKG 200
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L+ D++ HL + L AGF + SPVDVVK+R + Y S C +
Sbjct: 201 ALVNHHILADDVPCHLLSALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMTMYT 260
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF P+F RLGSW
Sbjct: 261 KEGPAAFFKGFAPSFLRLGSW 281
>sp|P12242|UCP1_MOUSE Mitochondrial brown fat uncoupling protein 1 OS=Mus
musculus GN=Ucp1 PE=2 SV=2
Length = 307
Score = 164 bits (414), Expect = 1e-039
Identities = 95/261 (36%), Positives = 132/261 (50%), Gaps = 8/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
+I T PLDTAKVRLQ+Q + +Y+G+LGT+ T+A+ EGL L+ G+ G+
Sbjct: 28 DIITFPLDTAKVRLQIQGEGQASSTI-----RYKGVLGTITTLAKTEGLPKLYSGLPAGI 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ Y + + PT++VKVR+
Sbjct: 83 QRQISFASLRIGLYDSVQE-YFSSGRETPASLGNKISAGLMTGGVAVFIGQPTEVVKVRM 141
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E + LW G P EL +YD +K
Sbjct: 142 QAQSHL-HGIKPRYTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKG 200
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L+ D++ HL + L AGF + SPVDVVK+R + Y S C +
Sbjct: 201 ALVNNKILADDVPCHLLSALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMSMYT 260
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF+ +F RLGSW
Sbjct: 261 KEGPTAFFKGFVASFLRLGSW 281
>sp|Q9ER18|UCP1_PHOSU Mitochondrial brown fat uncoupling protein 1 OS=Phodopus
sungorus GN=UCP1 PE=2 SV=1
Length = 307
Score = 163 bits (410), Expect = 3e-039
Identities = 95/261 (36%), Positives = 131/261 (50%), Gaps = 8/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
+I T PLDTAKVRLQ+Q + +Y+G+LGT+ T+A+ EGL L+ G+ G+
Sbjct: 28 DIITFPLDTAKVRLQIQGEGQTSSTI-----RYKGVLGTITTLAKTEGLPKLYSGLPAGI 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ Y + + PT++VKVRL
Sbjct: 83 QRQISFASLRIGLYDTVQE-YFSSGKETPPTLVNRISAGLMTGGVAVFIGQPTEVVKVRL 141
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E + LW G P EL +YD +K
Sbjct: 142 QAQSHL-HGIKPRYTGTYNAYRIIATTESLSTLWKGTTPNLLRNVIINCTELVTYDLMKG 200
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L+ D++ HL + L AGF + SP DVVK+R + Y S C +
Sbjct: 201 ALVNNQILADDVPCHLLSALVAGFCTTFLASPADVVKTRFINSLPGQYPSVPSCAMTMFT 260
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF+P+F RL SW
Sbjct: 261 KEGPTAFFKGFVPSFLRLASW 281
>sp|P14271|UCP1_RABIT Mitochondrial brown fat uncoupling protein 1
OS=Oryctolagus cuniculus GN=UCP1 PE=2 SV=1
Length = 306
Score = 162 bits (409), Expect = 4e-039
Identities = 93/261 (35%), Positives = 134/261 (51%), Gaps = 9/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
++ T PLDTAKVR Q+Q + +Y+G+LGT+ T+A+ EG L+ G+ GL
Sbjct: 28 DVITFPLDTAKVRQQIQGEFPITSGI-----RYKGVLGTITTLAKTEGPLKLYSGLPAGL 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ + + + + PT++VKVRL
Sbjct: 83 QRQISFASLRIGLYDTVQEFFTSGEETPSL--GSKISAGLTTGGVAVFIGQPTEVVKVRL 140
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E + +LW G P EL +YD +K
Sbjct: 141 QAQSHL-HGLKPRYTGTYNAYRIIATTESLTSLWKGTTPNLLRNVIINCTELVTYDLMKG 199
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L++ D++ H + L AGF + SPVDVVK+R + Y S +C +
Sbjct: 200 ALVRNEILADDVPCHFVSALIAGFCTTLLSSPVDVVKTRFINSPPGQYASVPNCAMTMFT 259
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF+P+F RLGSW
Sbjct: 260 KEGPTAFFKGFVPSFLRLGSW 280
>sp|Q8K404|UCP1_DICGR Mitochondrial brown fat uncoupling protein 1
OS=Dicrostonyx groenlandicus GN=UCP1 PE=2 SV=1
Length = 307
Score = 161 bits (407), Expect = 7e-039
Identities = 95/261 (36%), Positives = 130/261 (49%), Gaps = 8/261 (3%)
Frame = -3
Query: 781 EICTIPLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGL 602
+I T PLDTAKVRLQ+Q + +Y+G+LGT+ T+A+ EG L+ G+ G+
Sbjct: 28 DIITFPLDTAKVRLQIQGEGQTSSTI-----RYKGVLGTITTLAKTEGWPKLYSGLPAGI 82
Query: 601 HRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXXXXXXXXXXXXXXXVANPTDLVKVRL 422
RQ + LRIGLYD ++ Y + + PT++VKVRL
Sbjct: 83 QRQISFASLRIGLYDTVQE-YFSSGKETPPTLGNRISAGLMTGGVAVFIGQPTEVVKVRL 141
Query: 421 QAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQ 242
QA+ L G RY+G NAY I E LW G P EL +YD +K
Sbjct: 142 QAQSHL-HGIKPRYTGTYNAYRIIATTESFSTLWKGTTPNLMRNVIINRTELVTYDLMKG 200
Query: 241 TLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKSRMMGD-SAAYKSTIDCFVKTLK 65
L+ D++ HL + L AGF + SP DVVK+R + Y S C + L
Sbjct: 201 ALVNNQILADDVPCHLLSALVAGFCTTFLASPADVVKTRFINSLPGQYPSVPSCAMTMLT 260
Query: 64 NDGPLAFYKGFIPNFGRLGSW 2
+GP AF+KGF+P+F RL SW
Sbjct: 261 KEGPTAFFKGFVPSFLRLASW 281
>sp|P10861|UCP1_BOVIN Mitochondrial brown fat uncoupling protein 1 (Fragment)
OS=Bos taurus GN=UCP1 PE=2 SV=2
Length = 288
Score = 153 bits (384), Expect = 3e-036
Identities = 83/230 (36%), Positives = 121/230 (52%), Gaps = 5/230 (2%)
Frame = -3
Query: 688 KYRGMLGTVATVAREEGLSALWKGIVPGLHRQCLYGGLRIGLYDPIKTLYVGNDFVGDVP 509
+Y+G+LGT+ T+A+ EG L+ G+ GL RQ LRIGLYD ++ + +
Sbjct: 38 RYKGVLGTIITLAKTEGPVKLYSGLPAGLQRQISLASLRIGLYDTVQEFFTTGK---EAS 94
Query: 508 XXXXXXXXXXXXXXXXXVANPTDLVKVRLQAEGKLPPGAPRRYSGALNAYSTILRQEGVG 329
+ PT++VKVRLQA+ L G RY+G NAY I EG+
Sbjct: 95 LGSKISAGLMTGGVAVFIGQPTEVVKVRLQAQSHL-HGPKPRYTGTYNAYRIIATTEGLT 153
Query: 328 ALWTGIGPXXXXXXXXXXXELASYDQVKQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGS 149
LW G P EL +YD +K+ L+K D++ H + + AGF + S
Sbjct: 154 GLWKGTSPNLTTNVIINCTELVTYDLMKEALVKNKLLADDVPCHFVSAVVAGFCTTVLSS 213
Query: 148 PVDVVKSRMMGDSAAYKSTI-DCFVKTLKNDGPLAFYKGFIPNFGRLGSW 2
PVDVVK+R + S +++ +C + L +GP AF+KGF+P+F RLGSW
Sbjct: 214 PVDVVKTRFVNSSPGQNTSVPNCAMMMLTREGPSAFFKGFVPSFLRLGSW 263
>sp|Q54PY7|M2OM_DICDI Probable mitochondrial 2-oxoglutarate/malate carrier
protein OS=Dictyostelium discoideum GN=ucpC PE=3 SV=1
Length = 318
Score = 140 bits (352), Expect = 2e-032
Identities = 83/227 (36%), Positives = 109/227 (48%), Gaps = 8/227 (3%)
Frame = -3
Query: 682 RGMLGTVATVAREEGLSALWKGIVPGLHRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXX 503
RG L + + + EG L+KG+ L RQ Y R GLYD IK + +D +P
Sbjct: 65 RGALKMLVHINQTEGFFTLYKGLSASLLRQATYTTTRFGLYDLIKDIVAKDD--KPLPFT 122
Query: 502 XXXXXXXXXXXXXXXVANPTDLVKVRLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGAL 323
V P DL VR+QA+GKLP R Y + I ++EG+ +L
Sbjct: 123 QKIMVGMLSGAGGAIVGTPADLTMVRMQADGKLPFNLRRNYKNVFDGIFRISKEEGIISL 182
Query: 322 WTGIGPXXXXXXXXXXXELASYDQVKQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPV 143
W G P +++SYDQ KQ +L F D+I THL A A F A SP+
Sbjct: 183 WKGCSPNLIRAMFMTAGQVSSYDQTKQLMLASGYFHDDIKTHLIASTTAAFVAAVATSPL 242
Query: 142 DVVKSRMMGD------SAAYKSTIDCFVKTLKNDGPLAFYKGFIPNF 20
DV+K+R+M YK T DC KTL+ +G AFYKGF P F
Sbjct: 243 DVIKTRIMNSPKTVTGELQYKGTFDCLSKTLRAEGFKAFYKGFNPYF 289
>sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos
taurus GN=SLC25A11 PE=1 SV=3
Length = 314
Score = 122 bits (306), Expect = 3e-027
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 15/257 (5%)
Frame = -3
Query: 766 PLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGLHRQCL 587
PLD K R+QL + +Y+ + ++ R EGL ++ G+ GL RQ
Sbjct: 41 PLDLVKNRMQLSGEGAKTR-------EYKTSFHALISILRAEGLRGIYTGLSAGLLRQAT 93
Query: 586 YGGLRIGLYDPIKTLYVGNDFVGDVP-XXXXXXXXXXXXXXXXXVANPTDLVKVRLQAEG 410
Y R+G+Y + G D G P V P ++ +R+ A+G
Sbjct: 94 YTTTRLGIYTVLFERLTGAD--GTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADG 151
Query: 409 KLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQTLLK 230
+LP R Y NA I+++EGV LW G P +LASY Q KQ LL
Sbjct: 152 RLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLD 211
Query: 229 IPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKS-----RMMGDSAAYKSTIDCFVKTLK 65
F DNI+ H A + +G PVD+VK+ RM+ YK+ +D VK ++
Sbjct: 212 SGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVR 271
Query: 64 NDGPLAFYKGFIPNFGR 14
+G + +KGF P + R
Sbjct: 272 YEGFFSLWKGFTPYYAR 288
>sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier protein OS=Mus
musculus GN=Slc25a11 PE=1 SV=3
Length = 314
Score = 122 bits (305), Expect = 4e-027
Identities = 77/257 (29%), Positives = 114/257 (44%), Gaps = 15/257 (5%)
Frame = -3
Query: 766 PLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGLHRQCL 587
PLD K R+QL + +Y+ + ++ + EGL ++ G+ GL RQ
Sbjct: 41 PLDLVKNRMQLSGEGAKTR-------EYKTSFHALTSILKTEGLKGIYTGLSAGLLRQAT 93
Query: 586 YGGLRIGLYDPIKTLYVGNDFVGDVP-XXXXXXXXXXXXXXXXXVANPTDLVKVRLQAEG 410
Y R+G+Y + G D G P V P ++ +R+ A+G
Sbjct: 94 YTTTRLGIYTVLFERLTGAD--GTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADG 151
Query: 409 KLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQTLLK 230
+LP R Y NA I R+EGV LW G P +LASY Q KQ LL
Sbjct: 152 RLPADQRRGYKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLD 211
Query: 229 IPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKS-----RMMGDSAAYKSTIDCFVKTLK 65
F DNI+ H A + +G PVD+VK+ RM+ YK+ +D +K ++
Sbjct: 212 SGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLLKVVR 271
Query: 64 NDGPLAFYKGFIPNFGR 14
+G + +KGF P + R
Sbjct: 272 YEGFFSLWKGFTPYYAR 288
>sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier OS=Mus musculus
GN=Slc25a10 PE=2 SV=2
Length = 287
Score = 119 bits (298), Expect = 3e-026
Identities = 71/217 (32%), Positives = 101/217 (46%), Gaps = 2/217 (0%)
Frame = -3
Query: 676 MLGTVATVAREEGLSALWKGIVPGLHRQCLYGGLRIGLYDPIKTLYVGNDFVGDVPXXXX 497
M G V R +G AL+ G+ L RQ Y R +Y+ ++ Y+ D G +P
Sbjct: 43 MTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRD-YMTKDSQGPLPFYNK 101
Query: 496 XXXXXXXXXXXXXVANPTDLVKVRLQAEGKLPPGAPRRYSGALNAYSTILRQEGVGALWT 317
V P DLV VR+Q + KLPP R YS AL+ + R+E + L++
Sbjct: 102 VLLGGISGLTGGFVGTPADLVNVRMQNDMKLPPSQRRNYSHALDGLYRVAREESLRKLFS 161
Query: 316 GIGPXXXXXXXXXXXELASYDQVKQTLLKIPGFKDNIVTHLFAGLGAGFFAVCIGSPVDV 137
G +L+ YDQ KQ +L DNI TH + AG A + P+DV
Sbjct: 162 GATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVSSFIAGGCATFLCQPLDV 221
Query: 136 VKSRMMGDSAAYKSTIDCFVKTLKNDGPLAFYKGFIP 26
+K+R+M Y+ C ++T K GP AF+KG P
Sbjct: 222 LKTRLMNSKGEYQGVFHCAMETAKL-GPQAFFKGLFP 257
>sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein
OS=Homo sapiens GN=SLC25A11 PE=1 SV=3
Length = 314
Score = 119 bits (296), Expect = 5e-026
Identities = 76/257 (29%), Positives = 112/257 (43%), Gaps = 15/257 (5%)
Frame = -3
Query: 766 PLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGLHRQCL 587
PLD K R+QL + +Y+ + ++ + EGL ++ G+ GL RQ
Sbjct: 41 PLDLVKNRMQLSGEGAKTR-------EYKTSFHALTSILKAEGLRGIYTGLSAGLLRQAT 93
Query: 586 YGGLRIGLYDPIKTLYVGNDFVGDVP-XXXXXXXXXXXXXXXXXVANPTDLVKVRLQAEG 410
Y R+G+Y + G D G P V P ++ +R+ A+G
Sbjct: 94 YTTTRLGIYTVLFERLTGAD--GTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADG 151
Query: 409 KLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQTLLK 230
+LP R Y NA I R+EGV LW G P +LASY Q KQ LL
Sbjct: 152 RLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLD 211
Query: 229 IPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKS-----RMMGDSAAYKSTIDCFVKTLK 65
F DNI+ H A + +G PVD+ K+ RM+ YK+ +D K ++
Sbjct: 212 SGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVR 271
Query: 64 NDGPLAFYKGFIPNFGR 14
+G + +KGF P + R
Sbjct: 272 YEGFFSLWKGFTPYYAR 288
>sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carrier protein
OS=Rattus norvegicus GN=Slc25a11 PE=2 SV=3
Length = 314
Score = 118 bits (295), Expect = 6e-026
Identities = 76/257 (29%), Positives = 114/257 (44%), Gaps = 15/257 (5%)
Frame = -3
Query: 766 PLDTAKVRLQLQKKXXXXXXXXXXLPKYRGMLGTVATVAREEGLSALWKGIVPGLHRQCL 587
PLD R+QL + +Y+ + ++ + EGL ++ G+ GL RQ
Sbjct: 41 PLDLVXNRMQLSGEGAKTR-------EYKTSFHALTSILKAEGLRGIYTGLSAGLLRQAT 93
Query: 586 YGGLRIGLYDPIKTLYVGNDFVGDVP-XXXXXXXXXXXXXXXXXVANPTDLVKVRLQAEG 410
Y R+G+Y + G D G P V P ++ +R+ A+G
Sbjct: 94 YTTTRLGIYTVLFERLTGAD--GTPPGFLLKALIGMTAGATGAFVGPPAEVALIRMTADG 151
Query: 409 KLPPGAPRRYSGALNAYSTILRQEGVGALWTGIGPXXXXXXXXXXXELASYDQVKQTLLK 230
+LP R Y NA I R+EGV LW G P +LASY Q KQ LL
Sbjct: 152 RLPADQRRGYKNVFNALIRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLD 211
Query: 229 IPGFKDNIVTHLFAGLGAGFFAVCIGSPVDVVKS-----RMMGDSAAYKSTIDCFVKTLK 65
F DNI+ H A + +G PVD+VK+ RM+ + YK+ +D +K ++
Sbjct: 212 SGYFSDNILCHFCAIMISGLVTTAASMPVDIVKTRIQNMRMIDEKPEYKNGLDVLLKVVR 271
Query: 64 NDGPLAFYKGFIPNFGR 14
+G + +KGF P + R
Sbjct: 272 YEGFFSLWKGFTPYYAR 288
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,639,061,295
Number of Sequences: 462764
Number of Extensions: 27639061295
Number of Successful Extensions: 270866551
Number of sequences better than 0.0: 0
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